Communications in Information and Systems
Volume 19 (2019)
Comparison of two algorithms of direct coupling analysis of protein
Pages: 1 – 15
It has been shown that the residue-residue contacts in protein tertiary structures can be inferred from sequence coevolution information by using direct coupling analysis (DCA). This has greatly advanced protein structure prediction. However, current DCA algorithms still give many false positives and need further improvements. Here we analyze two popular algorithms of DCA: mean-field approximation (mfDCA) and pseudo-likelihood maximization (plmDCA). We compare their performances and suggest a simple method to reduce the false positives.
This work is supported by the NSFC under Grant No. 31570722 and 11874162.
Published 18 April 2019